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Out of a consecutive series of 50 young people less than 45 years old with nonhemorrhagic arterial stroke,three patients had inherited protein C deficiency.CT revealed hypodense areas consistent with the clinical picture,and angiography showed occlusion of some intracranial arterial vessels.other possible associated causes of stroke were ruled out.One patient had a transient ischemic attack and a peripheral venous thrombosis prior to the actual stroke,whereas the others were completely asymptomatic,as were relatives with the same deficiency.We suggest determining protein C in ischemic stroke of all young adults,especially when major risk factors are excluded. |
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